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Education

2018

2014

2012

2008

Ph.D. in Geochemistry - Medical Application; with jury's congratulations 

ENS Lyon, France  in collaboration with  EPFL Lausanne, Switzerland
Thesis Title: Ageing and neurodegenerative diseases: New constraints from the metallomic
Thesis Advisor: Dr. Vincent Balter

M.Sc. in Earth Sciences and Environment; with honors (5/57) 

University Joseph Fourier, Grenoble, France

B.Sc. in Earth Sciences and Environment; with honors (1/59) 

University Joseph Fourier, Grenoble, France

French High-School Diploma - speciality physics/chemistry; with first-class distinction 

High school Albert Triboulet, Romans-sur-Isère, France

Former & Current Professional Experiences 

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Licence Project (3rd year) (May 2012 - June 2012)

Title: Pb-Sr isotopic compositions of basaltic adzes from French Polynesia

Description: Using high precision liquid chromatography - mass spectrometry (LC-MS) techniques, I have measured and compared Pb and Sr isotopic compositions between adzes (archeological tools) from Tubuai island and rock samples collected in three different islands of French Polynesia (Eiao, Mangaia and Tubuai) to determine the provenance of the adzes and highlight potential inter-island trades.

Associated publication: Hermann A., Sauzéat L., Guillou H., Maury R.C., Chauvel C., Liorzou C., Conte E., 2017. Combined geochemical and geochronological analyses of stone artefacts provide unambiguous evidence of intra- and inter-island interactions in Polynesia. Journal of Archaeological Science: Reports 13, 75–87

Postdoctoral Project  (June 2018 - June 2019)

Title: Intracellular selenium speciation in low-concentrated biological samples

Description: In this project I worked on the development of a multi-step method involving microwave-assisted cell disruption combined with liquid chromatography and mass spectrometry to analyze intracellular speciation of Se in low-concentrated biological samples.

Scientific communication: Béziat P., Bouchet S., Sauzéat L., Tolu J., Alcolombri U., Winkel L., 2019. The role of phytoplankton in marine selenium cycling. Goldschmidt 2019

PhD Project (April 2015 - April 2018)

Title: Ageing and neurodegenerative diseases: New constraints

from the metallomic

Description:

I used chemical and Cu-Zn isotopic compositions of various biological

samples such as mice organs, human cerebrospinal fluids and cell cultures

to study ageing and neurodegenerative diseases development. Special attention was paid to the high-precision isotopic analysis of Cu and Zn necessitating robust sample preparation procedures and analytical techniques (i.e. liquid chromatography – mass spectrometry (LC-MS)). 

In the case of collaborations, I also analyze the chemical and Cu-Zn isotopic compositions of corals to better understand how climate changes affect coral lifespan.

Associated publication:

  • Sauzéat L., Laurençon A., Balter V., Metallome evolution in ageing C.elegans and a copper stable isotope perspective; Metallomics 10, 496-503

  • Garçon M., Sauzéat L., Carlson R.W., Shirey S.B., Simon M., Balter V., Boyet M., 2017. Nitrile, Latex, Neoprene and Vinyl Gloves: A Primary Source of Contamination for Trace Element and Zn Isotopic Analyses in Geological and Biological Samples. Geostandards and Geoanalytical Research 41, 367–380. 

  • Ferrier-Pagès C., Sauzéat L., Balter V., Coral bleaching is linked to the capacity of the animal host to supply essential metals to the symbionts; Global Change Biology 00, 1-13

  • Morel JD*, Sauzéat L*, Goeminne L.J.E., Jha P., Williams E., Houtkooper R.H., Aebersold R., Auwer J., Balter V., The mouse metallomic landscape of aging and metabolism. Nat Commun. 2022;13(1):607. doi:10.1038/s41467-022-28060-x. *First author. 

  • Sauzéat L., Bernard E., Perret-Liaudet A., Quadrio I., Vighetto A., Krolak-Salmon P., Broussolle E., Leblanc P., Balter V., Isotopic evidence for disrupted copper metabolism incerebrospinal fluids of ALS patients; submitted to Science advances

Master Project (1st year) (January 2013 - June 2013)

Title: How kimberlites form : clues from olivine geochemistry

Description: We have conducted petrological studies and microprobe analyses along several profiles in a dunitic polycristalline nodule from a very well preserved kimberlite from Kangamiut in Greenland in the aim to understand how kimberlites form.

Associated publication: Cordier C., Sauzéat L., Arndt N.T., Boullier A.-M., Batanova V., Barou F., 2015. Metasomatism of the Lithospheric Mantle Immediately Precedes Kimberlite Eruption: New Evidence from Olivine Composition and Microstructures. Journal of Petrology 56, 1775–1796

Postdoctoral Fellow  (PI, Jan 2020 - Oct 2021)

Title: Volcanic risk & Health 

Description: Metallome deregulation & Health disorders induced by artificial volcanic particles exposure: A proof-of-concept study 

Associated publication: 

  • Sauzéat L., Eychenne J., Gurioli L., et al., Metallome deregulation and health-related impacts due to long-term exposure to recent volcanic ash deposits: New chemical and isotopic insights; Sc.  of Tot. Env., 2022, 829, 154383, doi:10.1016/j.scitotenv.2022.154383

Master Project (2nd year) (January 2014 - January 2015)

Title: New perspectives on the Li isotopic composition of the upper continental crust (UCC) and its weathering signature

Description: Loess deposits are windblown sediments produced by mechanical erosion and thus experienced little chemical weathering during their formation. These features allow loess deposits to be considered as excellent proxies for the average UCC composition. Based on these information, we focus on desert loess deposits from several part of the world to better constrain the lithium composition of the UCC and provide supplementary information on its weathering intensity through time. 

Associated publication: Sauzéat L., Rudnick R., Chauvel C., Garçon M., Tang M., 2015. New perspectives on the Li isotopic composition of the upper continental crust and its weathering signature. Earth and Planetary Science Letters 428, 181–192

Since October 2021

Current position

Scientific Activities & 
Responsibilities

Since 2022 IAVCEI (International Association of Volcanology & Chemistry of the Earth’s Interior)  membership

​

2022 

  • Organization of a regional workshop (co-management 50%) – Life after a PhD in Earth Sciences: How to get jobs outside Academia?

  • Member of the scientific and pedagogical committee – School scientific exhibition: ExpoScience Auvergne, Clermont-Ferrand, France

  • Supervision of a Master Student (6months, M. Moreira, LMV Clermont-Ferrand) – Volcanic Pollution & Health

​​

Since 2021 Reviewer for Peer-reviewed journals (e.g., Frontiers in Medicine, Global Biogeochemical cycles, …)

​

2021 

  • Organization of a Regional Workshop; Impact of environmental pollutants on human health, i-Site/OPGC (Clermont-Ferrand, France)

  • Broad Public Science Dissemination, Clermont Innovation Week (France) – Is living in a volcanic context dangerous?

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2020 

Laboratory council Member (LMV), France

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2019 

Supervision of a Master student (P. Béziat, ETH Zurich) – Selenium speciation & environmental cycle

​

2016 

Doctorate congress organization, Lyon, France

​

Since 2015 

EAG (European Association Geochemistry) and SFIS (French stable isotope society) membership

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2014 

Field trip (Canada, 10 days)

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